The most common treatment for hemophilia A is called replacement therapy.1 Concentrates of clotting factor VIII are the foundation of this treatment for hemophilia A and are administered as an infusion to help replace the clotting factor that's missing or low in the blood.1 Non-factor treatments are also available for hemophilia A in certain situations.2
You can do both prophylactic (ongoing) and on-demand (as-needed) replacement therapy at home. Many people learn to do the infusions at home for their child or for themselves. Home treatment has several advantages1:
Today, clotting factor VIII concentrates can be made without human plasma.1 These types of infusions are called recombinant clotting factors.1
“Things have changed. It’s nothing like it was before. My outlook for my son is bright.“ — Athena, parent
In the past 25+ years, significant advances have been made in the manufacturing of these recombinant clotting factors.2 Recombinant technology has helped produce treated factor concentrates that avoid the risk of human-viral contamination.2
When you have a bleeding disorder, certain proteins, called clotting factors, are missing from your blood.1 An infused factor treatment temporarily replaces these missing factors.1
Recombinant factor VIII was one of the first such approved treatments for hemophilia and no longer had the dangers of transmitting deadly blood-borne viruses that were previously derived from human plasma.3
The Medical and Scientific Advisory Council (MASAC) of the National Hemophilia Foundation (NHF) encourages the use of recombinant clotting factor products.4 Your HCP or your Hemophilia Treatment Center (HTC) will help you decide which is right for you.
Half-life is related to how long treatment can stay in your body and specifically how long it takes half of the dosage to clear from your body. The longer the half-life, the longer your treatment is present in your body.5 This allows you and your HCP to plan your treatment regimen so that your factor levels fit your lifestyle.
Pharmacokinetic (PK) profiles are created by combining factor-related data points for an individual patient. HCPs can then use an individual’s PK profile to better understand how quickly the patient’s body breaks down treatment and therefore how to tailor treatment to meet that patient’s specific needs.7
HCPs can use this data as well to help tailor an individual’s treatment based on how they compare to known symptom and treatment efficacy information.7
You can help your HCP tailor your treatment to your specific needs by keeping track of your bleeds, physical activity, and infusions. Mobile applications are available to track your bleeds and infusion times.8 You can ask your HCP or HTC about PK profiling options that are available to you to help individualize you or your child’s hemophilia treatment.6
Be prepared with questions so you can have better conversations with your healthcare provider.
You're not alone. More than 30% of hemophilia patients face inhibitors to their treatment.
Hemophilia Treatment Centers (HTCs) provide a range of education and support services.