Hemophilia with Inhibitors Treatment
Hemophilia with Inhibitors Treatment

Treatment for hemophilia with inhibitors

Inhibitors stop factor replacement treatment from working. So, hemophilia with inhibitors makes it harder to prevent and stop bleeds.1 Fortunately, several treatment options are available today and research for more is ongoing.1

“As long as you have a positive outlook, you can continue to fight whatever challenges you face.“ — Amalia, Takeda community educator

The treatment you get is based on the amount of inhibitors you have.2 Inhibitor levels can vary from person to person and over the course of time, inhibitor levels can also vary within the same person. These levels are called titer levels.3

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Individualizing treatment

Inhibitors are complex. The amount of inhibitors in the blood varies from person to person and within the same person over time.3 If you are diagnosed with inhibitors, your hemophilia care team will consider your inhibitor level, as well as your lifestyle and activities before prescribing one of the following treatment courses:

  • Bypassing Agents. Special treatments are used to treat people with a high inhibitor titer. Rather than replacing the missing factor, these medications go around (or bypass) the factors that are missing or insufficient to help the blood form a clot1
  • Non-Factor Therapy. A treatment for people with hemophilia A that does not require factor VIII replacement.1

Detecting inhibitors through surveillance

Since as many as a third of all hemophilia patients may develop inhibitors to their factor treatment, there are screening tests (also called “surveillance” tests) that can help detect inhibitors early on.5 The Bethesda assay is the most widely used method in the United States, while other tests include the activated partial thromboplastin time (APTT) test, specific measurements of clotting factors over time (typically 48 hours), as well as a variant of the Bethesda assay called the Nijmegen-Bethesda assay.5

Consult with your healthcare provider (HCP) and your Hemophilia Treatment Center (HTC) about surveillance testing options that are available to you.5

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  1. Inhibitors and hemophilia. Centers for Disease Control and Prevention website. https://www.cdc.gov/ncbddd/hemophilia/inhibitors.html. Reviewed May 9, 2019. Accessed August 21, 2019.
  2. What are the treatment options for inhibitors? World Federation of Hemophilia website https://www.wfh.org/en/page.aspx?pid=652. Updated March 2018. Accessed August 21, 2019.
  3. How are inhibitors diagnosed? World Federation of Hemophilia website. https://www.wfh.org/en/page.aspx?pid=648. Updated May 2012. Accessed August 21, 2019.
  4. National Hemophilia Foundation. Facts about inhibitors. https://www.hemophilia.org/sites/default/files/document/files/Facts-About-Inhibitors.pdf. Published 2017. Accessed August 26, 2019.
  5. Soucie JM, Miller CH, Kelly FM, et al; the CDC Inhibitor Surveillance Working Group. National surveillance for hemophilia inhibitors in the United States: summary report of an expert meeting. Am J Hematol. 2014;89(6):621-625. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472332/. Published April 10, 2014. Accessed August 21, 2019.